ELISA WWP1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjµgating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Immunogen:WW domain containing E3 ubiquitin protein ligase 1 Synonyms:AIP5, DKFZp434D2111, hSDRP1, TiµL1, WW domain containing protein 1, WWP1 Observed MW:95 kDa Uniprot ID:Q9H0M0 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IP, IHC, IF Recommended dilution:WB: 1:200-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200 Gene ID:11059 Research Area:Epigenetics, Signal Transduction, Metabolism