ELISA XRCC3 anti-

Quantity :100µL Clone Number: Aliases:CMM6 antibody; DNA repair protein XRCC3 antibody; RAD51 like antibody; X ray repair complementing defective repair in Chinese hamster antibody; X ray repair complementing defective repair in Chinese hamster cells 3 antibody; X ray repair cross complementing protein 3 antibody; X-ray repair cross-complementing protein 3 antibody; XRCC 3 antibody; XRCC3 antibody; XRCC3_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43542 Immunogen:SyntheQuantityd peptide derived from internal of XRCC3. Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; IHC:1:50-1:100, IF:1:100-1:500 Background:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thoµght to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thoµght to play a role in DNA repair by HR. Plays a role in regµLating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. Liu N., Mol. Cell 1:783-793(1998). Miller K.A., J. Biol. Chem. 277:8406-8411(2002). Liu N., Nucleic Acids Res. 30:1009-1015(2002). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:XRCC3 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism