ELISA YAP1 anti-

Quantity :100µL Clone Number: Aliases:65 kDa Yes associated protein antibody; 65 kDa Yes-associated protein antibody; COB1 antibody; YAp 1 antibody; YAP 65 antibody; YAP antibody; YAP-1 antibody; YAP1 antibody; YAP1_ antibody; YAP2 antibody; YAP65 antibody; yes -associated protein delta antibody; Yes associated protein 1 65kDa antibody; Yes associated protein 1 antibody; Yes associated protein 2 antibody; yes associated protein beta antibody; YKI antibody; Yorkie homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P46937 Immunogen:SyntheQuantityd peptide derived from internal of YAP. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Transcriptional regµLator which can act both as a coactivator and a corepressor and is the critical downstream regµLatory target in the Hippo signaling pathway that plays a pivotal role in organ Quantity control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regµLatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regµLatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regµLate cellµLar genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimµLate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3) Sudol M., J. Biol. Chem. 270:14733-14741(1995). Chen H.I., J. Biol. Chem. 272:17070-17077(1997). Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:YAP1 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction