ELISA WNK2 Antibody, HRP

Quantity :50µg Clone Number: Aliases:WNK2 antibody; KIAA1760 antibody; PRKWNK2 antibody; SDCCAG43 antibody; P/OKcl.13 antibody; Serine/threonine-protein kinase WNK2 antibody; EC 2.7.11.1 antibody; Antigen NY-CO-43 antibody; Protein kinase lysine-deficient 2 antibody; Protein kinase with no lysine 2 antibody; Serologically defined colon cancer antigen 43 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y3S1 Immunogen:Recombinant Serine/threonine-protein kinase WNK2 protein (1177-1464AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Serine/threonine kinase which plays an important role in the regµLation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regµLates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modµLating the activity of MAP2K1 and this modµLation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regµLators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WNK2 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction