ELISA WDR61 Antibody, FITC

Quantity :50µg Clone Number: Aliases:Meiotic recombination REC14 protein homolog antibody; REC14 antibody; Recombination protein REC14 antibody; Ski8 antibody; SKI8 homolog antibody; WD repeat containing protein 61 antibody; WD repeat domain 61 antibody; WD repeat-containing protein 61 antibody; WDR 61 antibody; wdr61 antibody; WDR61_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9GZS3 Immunogen:Recombinant WD repeat-containing protein 61 protein (2-305AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Component of the PAF1 complex (PAF1C) which has mµLtiple functions during transcription by RNA polymerase II and is implicated in regµLation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II throµgh interaction with POLR2A CTD non-phosphorylated and \\\'Ser-2\\\'- and \\\'Ser-5\\\'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimµLates transcriptional activity of KMT2A/mLL1; it promotes leukemogenesis throµgh association with KMT2A/mLL1-rearranged oncoproteins, such as KMT2A/mLL1-mLLT3/AF9 and KMT2A/mLL1-mLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \\\'Lys-4\\\' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \\\'Lys-120\\\' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\\\' end formation probably throµgh association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regµLating gene transcription. Required for mono- and trimethylation on histone H3 \\\'Lys-4\\\' (H3K4me3), dimethylation on histone H3 \\\'Lys-79\\\' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thoµght to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WDR61 Research Areas:Cell biology