ELISA WDR41 Antibody, Biotin

Quantity :50µL Clone Number: Aliases:FLJ10904 antibody; MSTP048 antibody; WD repeat domain 41 antibody; WD repeat protein 41 antibody; WD repeat-containing protein 41 antibody; WDR 41 antibody; WDR41 antibody; WDR41_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9HAD4 Immunogen:Recombinant WD repeat-containing protein 41 protein (7-284AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regµLates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regµLator of autophagy initiation by interacting with the ATG1/µLK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WDR41 Research Areas:Cell biology