ELISA WNK3 Antibody, HRP

Quantity :50µg Clone Number: Aliases:KIAA1566 antibody; PRKWNK 3 antibody; PRKWNK3 antibody; Protein kinase lysine deficient 3 antibody; Protein kinase lysine-deficient 3 antibody; Protein kinase with no lysine 3 antibody; Serine/threonine protein kinase WNK3 antibody; Serine/threonine-protein kinase WNK3 antibody; WNK 3 antibody; WNK lysine deficient protein kinase 3 antibody; Wnk3 antibody; WNK3_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BYP7 Immunogen:Recombinant Serine/threonine-protein kinase WNK3 protein (1018-1181AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Serine/threonine kinase which plays an important role in the regµLation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. RegµLates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WNK3 Research Areas:Signal transduction