ELISA WNK4 Antibody, FITC

Quantity :50µg Clone Number: Aliases:PHA 2B antibody; PHA2B antibody; PRKWNK 4 antibody; PRKWNK4 antibody; Protein kinase lysine deficient 4 antibody; Protein kinase lysine-deficient 4 antibody; Protein kinase with no lysine 4 antibody; Serine/threonine protein kinase WNK4 antibody; Serine/threonine-protein kinase WNK4 antibody; WNK lysine deficient protein kinase 4 antibody; Wnk4 antibody; WNK4_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96J92 Immunogen:Recombinant Serine/threonine-protein kinase WNK4 protein (828-1106AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Serine/threonine kinase which plays an important role in the regµLation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. RegµLates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecµLar switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WNK4 Research Areas:Signal transduction