ELISA WDR24 Antibody, Biotin

Quantity :50µL Clone Number: Aliases:C16orf21 antibody; DKFZp434F054 antibody; JFP7 antibody; LA16c-313D11.2 antibody; WD repeat-containing protein 24 antibody; wdr24 antibody; WDR24_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96S15 Immunogen:Recombinant GATOR complex protein WDR24 protein (1-298AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway throµgh the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regµLated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regµLation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WDR24 Research Areas:Cell biology