ELISA WWTR1 anti-

Quantity :100µL Clone Number: Aliases:DKFZP586I1419 antibody; FLJ27004 antibody; FLJ45718 antibody; OTTHUMP00000215994 antibody; OTTHUMP00000215995 antibody; OTTHUMP00000215996 antibody; OTTHUMP00000216001 antibody; TAZ antibody; Transcriptional co activator with PDZ binding motif antibody; Transcriptional coactivator with PDZ binding motif antibody; Transcriptional coactivator with PDZ-binding motif antibody; WW domain containing transcription regµLator 1 antibody; WW domain containing transcription regµLator protein 1 antibody; WW domain-containing transcription regµLator protein 1 antibody; WWTR 1 antibody; WWTR1 antibody; WWTR1_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9GZV5 Immunogen:Peptide sequence around aa.386~390 (V-E-S-A-L) derived from TAZ. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Transcriptional coactivator which acts as a downstream regµLatory target in the Hippo signaling pathway that plays a pivotal role in organ Quantity control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regµLatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regµLatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. RegµLates the nuclear accumµLation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. RegµLates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Kanai F., Marignani P.A., Sarbassova D., Yagi R. EMBO J. 19:6778-6791(2000) Lei Q.Y., Zhang H., Zhao B., Zha Z.Y. Mol. Cell. Biol. 28:2426-2436(2008) Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R. Nat. Cell Biol. 10:837-848(2008) Di Palma T., D'Andrea B., Liguori G.L., Liguoro A. Exp. Cell Res. 315:162-175(2009) Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WWTR1 Research Areas:Epigenetics and Nuclear Signaling;Stem cells