ELISA X anti-

Quantity :50µg Clone Number: Aliases:X antibody; Protein X antibody; HBx antibody; Peptide X antibody; pX antibody Product Type:Polyclonal Antibody Immunogen Species:Hepatitis B virus genotype D UniProt ID:O93195 Immunogen:Recombinant Hepatitis B virus genotype D Protein X protein (1-154AA) Raised in:Rabbit Reactivity:Hepatitis B virus genotype D Tested Applications:ELISA Background:MµLtifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellµLar carcinoma). Most of cytosolic activities involve modµLation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modµLate apoptosis by binding host CFLAR, a key regµLator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex woµLd otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimµLates transcription of many different viral and cellµLar transcription elements. Promoters and enhancers stimµLated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:X Research Areas:Others