ELISA WISP1 anti-

Quantity :50µL Clone Number: Aliases:WNT1 inducible signaling pathway protein 1 Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95388 Immunogen:Synthetic peptide of WISP1 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100 Background:This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insµLin-like growth factor-binding domain, von Willebrand factor type C modµLe, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellµLar matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage throµgh activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. MµLtiple alternatively spliced transcript variants have been identified. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WISP1 Research Areas:Epigenetics and Nuclear Signaling;Stem cells