ELISA WEE1 anti-

Quantity :50µg Clone Number: Aliases:DKFZp686I18166 antibody; EC 2.7.10.2 antibody; FLJ16446 antibody; MGC105683 antibody; OTTHUMP00000231338 antibody; OTTHUMP00000231339 antibody; Wee 1 antibody; WEE 1 homolog 1 (S. pombe) antibody; WEE1 antibody; WEE1 homolog (S. pombe) antibody; Wee1 homolog antibody; WEE1 homolog S. pombe antibody; Wee1 like protein kinase antibody; Wee1 tyrosine kinase antibody; Wee1+ homolog antibody; Wee1+ S. pombe homolog antibody; WEE1, S. pombe, homolog of antibody; WEE1, somatic antibody; Wee1-like protein kinase antibody; WEE1_ antibody; WEE1A antibody; Wee1A kinase antibody; WEE1hu antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P30291 Immunogen:Recombinant Wee1-like protein kinase protein (45-177AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Acts as a negative regµLator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on \'Tyr-15\'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on \'Tyr-15\' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WEE1 Research Areas:Epigenetics and Nuclear Signaling; Cell biology