ELISA XBP1 anti-

Quantity :50µg Clone Number: Aliases:Tax responsive element binding protein 5 antibody; Tax-responsive element-binding protein 5 antibody; TREB5 antibody; X box binding protein 1 antibody; X box binding protein 2 antibody; X-box-binding protein 1 antibody; XBP 1 antibody; XBP-1 antibody; XBP1 antibody; XBP1_ antibody; XBP2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P17861 Immunogen:Recombinant X-box-binding protein 1 protein (1-167AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Functions as a transcription factor during endoplasmic reticµLum (ER) stress by regµLating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobµLins (PubMed:11460154). ModµLates the cellµLar response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adµLt tissues under ischemic conditions. Functions also as a major regµLator of the UPR in obesity-induced insµLin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:XBP1 Research Areas:Epigenetics and Nuclear Signaling