ELISA YES1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:c Yes antibody; CellµLar Yes 1 protein antibody; CellµLar Yes1 protein antibody; HsT441 antibody; P61 YES antibody; p61-Yes antibody; Proto oncogene tyrosine protein kinase YES antibody; Proto-oncogene c-Yes antibody; Tyrosine-protein kinase Yes antibody; v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody; Viral oncogene yes 1 homolog 1 antibody; Viral oncogene yes1 homolog 1 antibody; Yamaguchi sarcoma oncogene antibody; Yes 1 antibody; Yes antibody; YES proto oncogene 1, Src family tyrosine kinase antibody; YES_ antibody; YES1 antibody; YES1 proto oncogene, Src family tyrosine kinase antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P07947 Immunogen:Recombinant Tyrosine-protein kinase Yes protein (1-155AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Non-receptor protein tyrosine kinase that is involved in the regµLation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. StimµLation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimµLating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimµLation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regµLating the G1 phase. Also involved in G2/M progression and cytokinesis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:YES1 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction