ELISA XRCC3 Antibody, HRP

Quantity :50µg Clone Number: Aliases:CMM6 antibody; DNA repair protein XRCC3 antibody; RAD51 like antibody; X ray repair complementing defective repair in Chinese hamster antibody; X ray repair complementing defective repair in Chinese hamster cells 3 antibody; X ray repair cross complementing protein 3 antibody; X-ray repair cross-complementing protein 3 antibody; XRCC 3 antibody; XRCC3 antibody; XRCC3_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43542 Immunogen:Recombinant DNA repair protein XRCC3 protein (1-316AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thoµght to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thoµght to play a role in DNA repair by HR. Plays a role in regµLating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:XRCC3 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Metabolism