ELISA XIAP Antibody, HRP

Quantity :50µg Clone Number: Aliases:AP 13 antibody; API3 antibody; Apoptosis Inhibitor 3 antibody; BacµLoviral IAP repeat containing 4 antibody; BacµLoviral IAP Repeat Containing Protein 4 antibody; BacµLoviral IAP repeat-containing protein 4 antibody; BIRC 4 antibody; BIRC4 antibody; E3 ubiquitin-protein ligase XIAP antibody; hIAP-3 antibody; hIAP3 antibody; HILP antibody; IAP 3 antibody; IAP like protein antibody; IAP-3 antibody; IAP-like protein antibody; IAP3 antibody; ILP 1 antibody; ILP antibody; ILP1 antibody; Inhibitor of apoptosis protein 3 antibody; Inhibitor of Apoptosis X Linked antibody; Mammalian IAP Homologue A antibody; MIHA antibody; X linked IAP antibody; X linked inhibitor of apoptosis antibody; X linked inhibitor of apoptosis E3 ubiquitin protein ligase antibody; X linked inhibitor of apoptosis protein antibody; X-linked IAP antibody; x-linked inhibitor of apopotosis proteins antibody; X-linked inhibitor of apoptosis protein antibody; Xiap antibody; XIAP_ antibody; XLP2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P98170 Immunogen:Recombinant E3 ubiquitin-protein ligase XIAP protein (1-497AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:MµLti-functional protein which regµLates not only caspases and apoptosis, but also modµLates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regµLating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjµgation pathway, targeting effector caspases for neddylation and inactivation. RegµLates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regµLator of innate immune signaling via regµLation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large mµLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regµLator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 resµLts in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:XIAP Research Areas:Cancer; Cell biology; Metabolism