ELISA XBP1 anti-

Quantity :100µL Clone Number: Aliases:Tax responsive element binding protein 5 antibody; Tax-responsive element-binding protein 5 antibody; TREB5 antibody; X box binding protein 1 antibody; X box binding protein 2 antibody; X-box-binding protein 1 antibody; XBP 1 antibody; XBP-1 antibody; XBP1 antibody; XBP1_ antibody; XBP2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P17861 Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of XBP1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IF; WB:1:500-1:2000, IF:1:50-1:200 Background:This gene encodes a transcription factor that regµLates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellµLar transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumµLation of unfolded proteins in the endoplasmic reticµLum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resµLting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thoµght to function as a negative feedback regµLator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. Clonality:Polyclonal Isotype:IgG Purification Method:Affinity purification Conjµgate:Non-conjµgated Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:XBP1 Research Areas:Epigenetics and Nuclear Signaling