ELISA WWP2 Antibody, FITC

Quantity :50µg Clone Number: Aliases:WWP2NEDD4-like E3 ubiquitin-protein ligase WWP2 antibody; EC 2.3.2.26 antibody; Atrophin-1-interacting protein 2 antibody; AIP2 antibody; HECT-type E3 ubiquitin transferase WWP2 antibody; WW domain-containing protein 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O00308 Immunogen:Recombinant NEDD4-like E3 ubiquitin-protein ligase WWP2 protein (145-367AA) Raised in:Rabbit Reactivity: Tested Applications: Background:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjµgating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by \\\'Lys-63\\\'-linked conjµgation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regµLate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WWP2 Research Areas:Epigenetics and Nuclear Signaling; Cell biology