ELISA WNT5A Antibody, Biotin

Quantity :50µg Clone Number: Aliases:hWNT 5A antibody; hWNT5A antibody; Protein Wnt 5a antibody; Protein Wnt-5a antibody; Protein Wnt5a antibody; Wingless type MMTV integration site family member 5A antibody; Wnt 5a antibody; WNT 5A protein antibody; WNT 5A protein precursor antibody; WNT5A antibody; WNT5A protein precursor antibody; WNT5A_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P41221 Immunogen:Recombinant Protein Wnt-5a protein (62-380AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation throµgh a GSK3-independent pathway which involves down-regµLation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. StimµLates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WNT5A Research Areas:Neuroscience; Cancer; Signal transduction; Stem cells